Encapsulation
Encapsulation — The process of enclosing peptides within a protective shell or matrix such as liposomes or nanoparticles to improve stability and delivery.
What Is Encapsulation?
Encapsulation is the entrapment of a peptide within a protective carrier system (liposomes, nanoparticles, micelles, hydrogels, PLGA microspheres) to improve stability, control release, protect from degradation, and enhance cellular uptake.
Encapsulation Methods
- PLGA microspheres: Double emulsion (W/O/W) for depot formulations (Lupron Depot)
- Liposomes: Thin-film hydration or extrusion. 50-200 nm vesicles
- Chitosan NPs: Ionic gelation with tripolyphosphate for mucosal delivery
- Encapsulation efficiency: % of peptide entrapped vs. total added. Target > 50%
Frequently Asked Questions
What is Encapsulation?
The process of enclosing peptides within a protective shell or matrix such as liposomes or nanoparticles to improve stability and delivery.
Why is Encapsulation important in peptide research?
Encapsulation is a fundamental concept in technology as it relates to peptide science. It directly influences experimental design, compound characterization, and the reliability of research outcomes across biochemistry and molecular biology disciplines.