Drug Delivery System
Drug Delivery System — A formulation or device designed to deliver a peptide compound to a specific site at a controlled rate, overcoming barriers like enzymatic degradation and poor absorption.
What Is a Drug Delivery System?
A drug delivery system (DDS) is a technology that controls the rate, time, and location of peptide release in the body. DDS addresses the key limitations of peptide therapeutics: short half-life, poor oral bioavailability, and need for frequent injection by providing sustained, targeted, or non-invasive delivery.
Delivery Platforms
- PLGA microspheres: Monthly/quarterly depots. Lupron Depot, Sandostatin LAR
- Liposomes: 50-200 nm lipid vesicles for IV peptide delivery
- Hydrogels: Injectable in situ-forming gels for localized sustained release
- Oral: Enteric coating + permeation enhancers (Rybelsus oral semaglutide model)
Frequently Asked Questions
What is Drug Delivery System?
A formulation or device designed to deliver a peptide compound to a specific site at a controlled rate, overcoming barriers like enzymatic degradation and poor absorption.
Why is Drug Delivery System important in peptide research?
Drug Delivery System is a fundamental concept in technology as it relates to peptide science. It directly influences experimental design, compound characterization, and the reliability of research outcomes across biochemistry and molecular biology disciplines.
Authority Sources
- Drug Delivery System on Wikipedia
- Search Drug Delivery System on PubChem (NIH)
- Research articles on ScienceDirect