Selank
Selank — A synthetic heptapeptide analog of the immunomodulatory peptide tuftsin, studied for anxiolytic and nootropic properties in preclinical research models.
What Is Selank?
Selank is a synthetic heptapeptide with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro, developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. It is an analog of the naturally occurring immunomodulatory peptide tuftsin (Thr-Lys-Pro-Arg) with an added Pro-Gly-Pro tail that increases metabolic stability and extends its half-life.
With a molecular weight of 751.87 Da, Selank is classified as a synthetic analog of an endogenous immunopeptide. It has been studied extensively in Russian pharmacological literature, with over 100 published papers examining its neurotropic and anxiolytic properties.
Mechanism of Action
Selank exerts its effects primarily through modulation of the GABA system, serotonergic pathways, and brain-derived neurotrophic factor (BDNF) expression. Research has demonstrated that it influences the expression of 36 genes related to GABAergic signaling in hippocampal cell cultures.
The peptide also affects the balance of Th1/Th2 cytokine production, modulates IL-6 and interferons, and has been shown to influence the expression of BDNF and its receptor trkB, linking its immunomodulatory and neurotropic properties through shared molecular pathways.
Research Profile
- Anxiolytic effects: Studies in rodent models (elevated plus maze, open field tests) demonstrated reduced anxiety-like behavior without sedation or motor impairment
- Cognitive function: Research showed improvement in learning and memory tasks in animal models, potentially mediated through BDNF upregulation
- Immunomodulation: Selank enhanced phagocytic activity and modulated cytokine profiles in vitro, consistent with its tuftsin-based origin
- Neuroprotection: Cell culture studies demonstrated protective effects against oxidative stress and neurotoxin-induced cell death
Reconstitution and Storage
Selank is supplied as a white lyophilized powder. Store at -20°C. Reconstitute with bacteriostatic water. The reconstituted solution is stable at 2-8°C for up to 21 days. Protect from light, as the proline-rich sequence can undergo UV-mediated degradation.
Frequently Asked Questions
What is Selank?
A synthetic heptapeptide analog of the immunomodulatory peptide tuftsin, studied for anxiolytic and nootropic properties in preclinical research models.
Why is Selank important in peptide research?
Selank is a fundamental concept in compound as it relates to peptide science. It directly influences experimental design, compound characterization, and the reliability of research outcomes across biochemistry and molecular biology disciplines.