MK-677 (Ibutamoren)
MK-677 (Ibutamoren) — A non-peptide growth hormone secretagogue that mimics ghrelin activity, often studied alongside peptide-based GH research compounds.
What Is MK-677?
MK-677 (ibutamoren) is an orally active non-peptide ghrelin/growth hormone secretagogue receptor (GHS-R1a) agonist. Although not a peptide itself, MK-677 mimics the action of peptide GH secretagogues like GHRP-6 and ipamorelin, stimulating pulsatile GH release and increasing IGF-1 levels.
Research Profile
- Oral activity: Non-peptide peptidomimetic. ~60% oral bioavailability
- Half-life: 4-6 hours. Once-daily dosing maintains elevated IGF-1 for 24 hours
- GH pulsatility: Preserves natural pulsatile GH release pattern (unlike exogenous GH injection)
Frequently Asked Questions
What is MK-677 (Ibutamoren)?
A non-peptide growth hormone secretagogue that mimics ghrelin activity, often studied alongside peptide-based GH research compounds.
Why is MK-677 (Ibutamoren) important in peptide research?
MK-677 (Ibutamoren) is a fundamental concept in compound as it relates to peptide science. It directly influences experimental design, compound characterization, and the reliability of research outcomes across biochemistry and molecular biology disciplines.
Authority Sources
- MK-677 (Ibutamoren) on Wikipedia
- Search MK-677 (Ibutamoren) on PubChem (NIH)
- Research articles on ScienceDirect