Laminin
Laminin — A major glycoprotein of the basement membrane that promotes cell adhesion and differentiation, studied with cell-binding peptide fragments.
What Is Laminin?
Laminin is a major ECM glycoprotein of basement membranes, composed of alpha, beta, and gamma chains forming a cross-shaped heterotrimer. Laminin-derived peptides (YIGSR, IKVAV, SIKVAV) promote cell adhesion, neurite outgrowth, and angiogenesis, and are used to functionalize biomaterial scaffolds for neural tissue engineering.
Key Peptides
- YIGSR: From laminin beta-1 chain. Promotes neural cell adhesion via 67 kDa laminin receptor
- IKVAV: From laminin alpha-1 chain. Promotes neurite outgrowth. Used in neural scaffold design
- Anti-metastatic: YIGSR inhibits experimental metastasis by blocking tumor cell-basement membrane interaction
Frequently Asked Questions
What is Laminin?
A major glycoprotein of the basement membrane that promotes cell adhesion and differentiation, studied with cell-binding peptide fragments.
Why is Laminin important in peptide research?
Laminin is a fundamental concept in compound as it relates to peptide science. It directly influences experimental design, compound characterization, and the reliability of research outcomes across biochemistry and molecular biology disciplines.