KPV
KPV — A C-terminal tripeptide fragment (Lys-Pro-Val) of alpha-melanocyte-stimulating hormone, studied for anti-inflammatory properties in mucosal tissue models.
What Is KPV?
KPV is a tripeptide with the sequence Lys-Pro-Val (single-letter code: KPV) and a molecular weight of 342.43 Da. It corresponds to the C-terminal fragment of alpha-melanocyte-stimulating hormone (alpha-MSH, residues 11-13). Despite being only three amino acids, KPV retains significant anti-inflammatory activity attributed to the parent hormone.
Mechanism of Action
KPV exerts anti-inflammatory effects through inhibition of NF-kB nuclear translocation, reducing the transcription of pro-inflammatory cytokines including TNF-alpha, IL-1beta, and IL-6. Unlike full-length alpha-MSH, KPV does not activate melanocortin receptors (MC1R-MC5R), indicating a receptor-independent anti-inflammatory mechanism possibly involving direct intracellular uptake and NF-kB pathway interference.
Research Applications
- Inflammatory bowel disease: Studies in murine colitis models demonstrated reduced inflammation scores and preserved mucosal integrity
- Skin inflammation: Research showed reduced cytokine production in keratinocyte and macrophage cell cultures
- Wound healing: Studies demonstrated anti-inflammatory effects at wound sites without suppressing beneficial immune responses
- Oral delivery: Due to its small size and proline content, KPV shows some resistance to GI degradation
Handling
Store lyophilized at -20°C. KPV is highly water-soluble due to its small size and net positive charge. Reconstitute with bacteriostatic water. Use within 28 days at 2-8°C.
Frequently Asked Questions
What is KPV?
A C-terminal tripeptide fragment (Lys-Pro-Val) of alpha-melanocyte-stimulating hormone, studied for anti-inflammatory properties in mucosal tissue models.
Why is KPV important in peptide research?
KPV is a fundamental concept in compound as it relates to peptide science. It directly influences experimental design, compound characterization, and the reliability of research outcomes across biochemistry and molecular biology disciplines.