IGF-1 LR3
IGF-1 LR3 — A modified form of IGF-1 with an arginine substitution at position 3 and a 13-amino acid extension, resulting in reduced IGF-binding protein affinity.
What Is IGF-1 LR3?
IGF-1 LR3 (Long R3 IGF-1) is a modified 83-amino acid analog of IGF-1 with an arginine substitution at position 3 (Glu→Arg) and a 13-amino acid N-terminal extension. These modifications dramatically reduce binding to IGF-binding proteins (IGFBPs), increasing free IGF-1 bioactivity and extending functional half-life.
Research Profile
- IGFBP evasion: R3 substitution reduces IGFBP binding by > 100-fold vs. native IGF-1
- Free fraction: Nearly 100% free (unbound) vs. ~1% free for native IGF-1
- Cell culture: Standard supplement for serum-free media and proliferation assays
Frequently Asked Questions
What is IGF-1 LR3?
A modified form of IGF-1 with an arginine substitution at position 3 and a 13-amino acid extension, resulting in reduced IGF-binding protein affinity.
Why is IGF-1 LR3 important in peptide research?
IGF-1 LR3 is a fundamental concept in compound as it relates to peptide science. It directly influences experimental design, compound characterization, and the reliability of research outcomes across biochemistry and molecular biology disciplines.