Hexarelin
Hexarelin — A synthetic hexapeptide growth hormone secretagogue with strong GH-releasing activity, used in research on the ghrelin receptor pathway.
What Is Hexarelin?
Hexarelin (Examorelin) is a synthetic hexapeptide growth hormone secretagogue with the sequence His-D-2-Me-Trp-Ala-Trp-D-Phe-Lys-NH2 and a molecular weight of 887.04 Da. It is structurally related to GHRP-6 but contains a 2-methylated tryptophan at position 2, which increases its GH-releasing potency and adds unique cardioprotective properties not shared by other GHRP family members.
Mechanism of Action
Hexarelin activates both the GHS-R1a (ghrelin) receptor and the cardiac CD36 receptor. GHS-R1a activation on pituitary somatotrophs produces potent GH release. CD36 activation in cardiac tissue triggers protective signaling pathways independent of GH secretion, distinguishing hexarelin from other members of the GHRP family.
Research Applications
- GH secretion: One of the most potent GHRPs, with GH release comparable to GHRP-2 but with additional cardiac effects
- Cardioprotection: Studies demonstrated reduced infarct size, improved cardiac output, and anti-fibrotic effects through CD36-dependent pathways
- Desensitization: Unlike some GHRPs, hexarelin shows receptor desensitization with chronic dosing, reducing GH response over time
- Clinical data: Phase I/II trials in healthy volunteers and heart failure patients have been conducted
Storage
Store lyophilized at -20°C. Reconstitute with bacteriostatic water. Use within 21 days at 2-8°C.
Frequently Asked Questions
What is Hexarelin?
A synthetic hexapeptide growth hormone secretagogue with strong GH-releasing activity, used in research on the ghrelin receptor pathway.
Why is Hexarelin important in peptide research?
Hexarelin is a fundamental concept in compound as it relates to peptide science. It directly influences experimental design, compound characterization, and the reliability of research outcomes across biochemistry and molecular biology disciplines.