Fibronectin
Fibronectin — A high-molecular-weight glycoprotein that binds to integrins and extracellular matrix components, involved in cell adhesion, growth, and migration.
What Is Fibronectin?
Fibronectin is a large ECM glycoprotein (440 kDa dimer) containing the RGD tripeptide motif that mediates cell adhesion via integrin receptors. The RGD sequence from fibronectin's tenth type III domain is the most widely used cell adhesion peptide in biomaterials and the basis for integrin-targeting cancer therapeutics.
Peptide Derivatives
- RGD: Minimal integrin-binding motif. Linear and cyclic RGD peptides for targeting and biomaterial functionalization
- Cilengitide: Cyclic RGDf(NMe)V. Integrin αvβ3/αvβ5 antagonist tested in glioblastoma clinical trials
- FN III domains: Engineered fibronectin scaffolds (Adnectins) as non-antibody binding proteins
Frequently Asked Questions
What is Fibronectin?
A high-molecular-weight glycoprotein that binds to integrins and extracellular matrix components, involved in cell adhesion, growth, and migration.
Why is Fibronectin important in peptide research?
Fibronectin is a fundamental concept in compound as it relates to peptide science. It directly influences experimental design, compound characterization, and the reliability of research outcomes across biochemistry and molecular biology disciplines.