Cyclic Peptide
Cyclic Peptide — A peptide whose amino acid chain forms a ring structure through a bond between the termini or side chains, often conferring enhanced stability and bioactivity.
What Is a Cyclic Peptide?
A cyclic peptide contains a ring structure formed by a covalent bond between two parts of the chain. Cyclization can occur head-to-tail (N-to-C amide bond, creating a circular peptide), side-chain-to-side-chain (disulfide, lactam, staple), or side-chain-to-terminus. Cyclization dramatically improves protease resistance, binding affinity, and membrane permeability.
Approved Cyclic Peptide Drugs
- Cyclosporine A: 11-residue cyclic. Immunosuppressant. 30% oral bioavailability
- Octreotide: Disulfide-cyclized somatostatin analog
- Daptomycin: Cyclic lipopeptide antibiotic
Frequently Asked Questions
What is Cyclic Peptide?
A peptide whose amino acid chain forms a ring structure through a bond between the termini or side chains, often conferring enhanced stability and bioactivity.
Why is Cyclic Peptide important in peptide research?
Cyclic Peptide is a fundamental concept in structure as it relates to peptide science. It directly influences experimental design, compound characterization, and the reliability of research outcomes across biochemistry and molecular biology disciplines.
Authority Sources
- Cyclic Peptide on Wikipedia
- Search Cyclic Peptide on PubChem (NIH)
- Research articles on ScienceDirect