Corticotropin
Corticotropin — Another name for adrenocorticotropic hormone (ACTH), a 39-amino acid peptide that stimulates cortisol production from the adrenal glands.
What Is Corticotropin?
Corticotropin is another name for adrenocorticotropic hormone (ACTH), a 39-amino acid peptide hormone secreted by the anterior pituitary that stimulates the adrenal cortex to produce cortisol and other corticosteroids. Synthetic ACTH(1-24) (cosyntropin/tetracosactide) is used clinically as a diagnostic tool for adrenal insufficiency (ACTH stimulation test).
Clinical Use
- ACTH stim test: 250 µg IV cosyntropin. Measure cortisol at 0 and 60 min. Normal response > 18 µg/dL
- Acthar Gel: Repository corticotropin injection for infantile spasms and nephrotic syndrome
- Sequence: Active fragment ACTH(1-24) retains full biological activity of ACTH(1-39)
Frequently Asked Questions
What is Corticotropin?
Another name for adrenocorticotropic hormone (ACTH), a 39-amino acid peptide that stimulates cortisol production from the adrenal glands.
Why is Corticotropin important in peptide research?
Corticotropin is a fundamental concept in compound as it relates to peptide science. It directly influences experimental design, compound characterization, and the reliability of research outcomes across biochemistry and molecular biology disciplines.