Chloride Channel
Chloride Channel — A membrane protein that allows chloride ions to cross the cell membrane, a target studied in peptide toxin research and ion channel pharmacology.
What Is a Chloride Channel?
A chloride channel is a transmembrane protein that selectively conducts Cl⁻ ions across cell membranes. Several peptide toxins target chloride channels: chlorotoxin (36-AA scorpion peptide) blocks glioma-specific chloride channels and is used as a tumor-painting agent in neurosurgery. Peptide modulators of CFTR chloride channel are studied for cystic fibrosis.
Peptide Tools
- Chlorotoxin: 36-residue scorpion peptide with 4 disulfides. Binds MMP-2/ClC-3 on glioma cells. ICG-conjugated for tumor visualization
- CFTR peptides: Regulatory domain phosphopeptides modulating CFTR channel gating
- GlyR peptides: Glycine receptor (chloride channel) modulatory peptides for pain research
Frequently Asked Questions
What is Chloride Channel?
A membrane protein that allows chloride ions to cross the cell membrane, a target studied in peptide toxin research and ion channel pharmacology.
Why is Chloride Channel important in peptide research?
Chloride Channel is a fundamental concept in biology as it relates to peptide science. It directly influences experimental design, compound characterization, and the reliability of research outcomes across biochemistry and molecular biology disciplines.
Authority Sources
- Chloride Channel on Wikipedia
- Search Chloride Channel on PubChem (NIH)
- Research articles on ScienceDirect