Calmodulin
Calmodulin — A calcium-binding messenger protein that mediates many calcium-dependent signaling processes, interacting with numerous peptide substrates.
What Is Calmodulin?
Calmodulin (CaM) is a 148-residue calcium-binding protein that acts as a universal intracellular calcium sensor. Upon binding 4 Ca²⁺ ions, CaM undergoes a conformational change that exposes hydrophobic surfaces, enabling it to bind and activate target enzymes and channels. CaM-binding peptides are essential research tools for studying calcium-dependent signaling.
Peptide Tools
- CaM-binding peptides: Amphipathic helical peptides (M13, RS20) that mimic natural CaM targets
- CaM inhibitor peptides: Block CaM-dependent kinases and phosphatases
- Melittin: Bee venom peptide that binds CaM with high affinity
Frequently Asked Questions
What is Calmodulin?
A calcium-binding messenger protein that mediates many calcium-dependent signaling processes, interacting with numerous peptide substrates.
Why is Calmodulin important in peptide research?
Calmodulin is a fundamental concept in compound as it relates to peptide science. It directly influences experimental design, compound characterization, and the reliability of research outcomes across biochemistry and molecular biology disciplines.