Bombesin
Bombesin — A tetradecapeptide originally isolated from frog skin that stimulates gastrin release and smooth muscle contraction, studied in gastrointestinal peptide research.
What Is Bombesin?
Bombesin is a 14-amino acid neuropeptide originally isolated from frog skin that binds gastrin-releasing peptide receptors (GRP-R/BB2). GRP-R is overexpressed in prostate, breast, lung, and pancreatic cancers, making bombesin analogs important targeting peptides for cancer imaging and peptide-drug conjugates.
Applications
- Tumor imaging: ⁶⁸Ga-NOTA-bombesin for PET imaging of GRP-R+ tumors
- Targeted therapy: ¹⁷⁷Lu-bombesin conjugates for peptide receptor radionuclide therapy
- Analogs: [D-Phe⁶, β-Ala¹¹, Phe¹³, Nle¹⁴]-bombesin(6-14) = RM2 clinical imaging agent
Frequently Asked Questions
What is Bombesin?
A tetradecapeptide originally isolated from frog skin that stimulates gastrin release and smooth muscle contraction, studied in gastrointestinal peptide research.
Why is Bombesin important in peptide research?
Bombesin is a fundamental concept in compound as it relates to peptide science. It directly influences experimental design, compound characterization, and the reliability of research outcomes across biochemistry and molecular biology disciplines.