Absorption
Absorption — The process by which a compound enters the bloodstream from the site of administration, influenced by molecular size, charge, and lipophilicity.
What Is Absorption?
Absorption is the process by which a peptide moves from its administration site into the systemic circulation. It is the first step in the ADME (pharmacokinetic) process and the primary determinant of bioavailability. The rate and extent of absorption depend on the administration route, peptide properties, and formulation.
Absorption by Route
- IV: No absorption barrier. 100% bioavailability by definition
- SC/IM: Absorption through capillary fenestrations. Bioavailability 50-100%
- Intranasal: Absorption through nasal mucosa. Bioavailability 1-10% without enhancers
- Oral: Must survive GI enzymes and cross intestinal epithelium. Bioavailability < 2% for most peptides
Frequently Asked Questions
What is Absorption?
The process by which a compound enters the bloodstream from the site of administration, influenced by molecular size, charge, and lipophilicity.
Why is Absorption important in peptide research?
Absorption is a fundamental concept in pharmacology as it relates to peptide science. It directly influences experimental design, compound characterization, and the reliability of research outcomes across biochemistry and molecular biology disciplines.